WP4 Events

Objectives

WP leader Dr. Peteris Trapencieris

  • To facilitate the knowledge transfer at the national, regional and international levels;
  • To increase the visibility of LIOS by dissemination of the results of Latvian scientists in organic chemistry, medicinal chemistry of heterocycles, structure-activity relationships, experimental chemotherapy and pharmacology to the international scientific community;
  • To strengthen the long-lasting scientific collaboration between LIOS and partnering organisations in ERA.

Publication writing

On 25th February 2014 Workshop on publication and grant writing took place at the Latvian Institute of Organic Synthesis

Agenda

9.30 – 11.00 Scientific writing in chemistry, Professor Carsten Bolm, RWTH Aachen University, Germany.
11.00 – 11.30 Coffee break
11.30 -  13.00 Writing of competitive grant proposals, Professor Edvīns  Vedejs

    
    

 

Biophysical methods

Seminar  "Biophysical methods in drug discovery" will take place on September 22, 2015. Venue: Latvian Institute of Organic Synthesis, conference hall.

Agenda


June 5, 2015 Seminar “Molecular modeling in drug discovery” will take place in Latvian Institute of Organic Synthesis

Agenda


Seminar series "Biophysical Methods in Drug Discovery" focus on the use of biophysical methods for ligand screening, protein-ligand complex characterization and studies of mechanism of action. It includes three seminars covering applications of

  • nuclear magnetic resonance (NMR),
  • surface plasmon resonance (SPR),
  • modelling and X-ray crystallography

On 27th January 2014 the first seminar devoted to NMR application took place in Latvian Institute or Organic Synthesis.

Agenda of seminar

 

Protein production

InnovaBalt seminar

„Protein production techniques"

presented by

Professor Volker Dötsch

Institute of Biophysical Chemistry, Goethe University, Frankfurt/Main, Germany

21st April 2015, Conference Hall, Latvian Institute of Organic Synthesis

9.45-10.00 Registration and coffee
10.00-10.05 Welcome remarks
10.05-10.50 Combination of cell-free synthesis and NMR spectroscopy for the structure determination of membrane proteins
10.50-11.35 In-cell NMR studies for the investigation of the behavior of macromolecules in living cells
11.35-12.00 Coffee break
12.00-12.45 The tales of p63: investigation of the structure and function of p63, using a wide variety of techniques
12.45-13.15 Discussions and snacks
 

Horizon 2020

Training seminar “Competitive development of project ideas, writing of project proposals and implementation of projects within the EU science and innovation programme "Horizon2020" will take place on October 6-7, 2015. Venue: hotel “Monika”, Elizabetes str.21, hall "Glory", Riga.

Agenda


Training seminar "How ro prepare competitive proposal for Horizon2020" took place in Riga on 5th-6th June 2014. Training course leader  as Dr.Sean  McCarthy (Ltd Hyperion, www.hyperion.ie). The main topics of the training course:

•     Political background to Horizon 2020

•     Structure and terminology used in Horizon 2020

•     How proposals are evaluated

•     How to streamline the writing of the proposals

•     How to write the impact of the proposal

•     Legal, financial rules of Horizon2020

The analysis of two prepared proposals were carried out (proposal clinic).

 

Antiinfective drugs

On 27th May 2014 Seminar "Advanced anti-infective drug discovery and  design" took place in Riga"
Participation in the seminar is free of charge

Agenda of seminar

 

BOS-2014 pre-conference

Balticum Organicum Syntheticum (BOS-2014) pre-conference round table "New Therapeutic Targets: Chemistry and  Biology" took place on 3-4 July 2014 in Malpils.

Agenda

 

DrugDiscovery

Gallery - Photo from the Drug Discovery Conference and from the opening of the commemorative plaque in tribute to Professor Solomon Hiller, founder of Latvian Institute of Organic Synthesis

Latvian Institute of Organic Synthesis and the 7th EU FP project InnovaBalt have a great honour to invite you to participate in the Drug Discovery Conference, taking place August 27-29, 2015 at the Radisson Blu Hotel Latvia, Riga, Latvia. The Drug Discovery conference will cover topics starting from organic synthesis and medicinal chemistry to biological and pharmacological applications of novel ligands. Conference scientific program and discussions will be organized for chemists in organic and analytical chemistry and process development, as well as pharmacologists and biologists to present investigations of mechanistic aspects of developmental drugs. Session for the stakeholders will be organized. There will be a satellite seminar dedicated to the 50th anniversary of Chemistry of Heterocyclic Compound journal
http://hgs.osi.lv/index.php/hgs

Contacts: drugdiscoveryriga2015@gmail.com

WELCOME LETTER


          It is our privilege and pleasure to welcome you to the Drug Discovery Conference taking place in Riga. DDC2015 is organized by the Latvian Institute of Organic Synthesis, and the EC 7th Framework Program project „Strengthening the research and innovative capacities of the Latvian Institute of Organic Synthesis, the leading Baltic regional centre for drug discovery”, InnovaBalt.
          The aim of the DDC2015 is to bring together researchers exploring novel drug candidates and targets for applications in different therapeutic areas. In addition, DDC2015 will celebrate the 50th anniversary of Chemistry of Heterocyclic Compound journal and commemorate the history of the Latvian Institute of Organic Synthesis and drug discovery in Latvia.
          Exchange of opinions and communication are the most important components in the progress of scientific ideas. We are happy to present the scientific program of the DDC2015 covering different aspects of drug discovery in plenary lectures, oral presentations and poster sessions. The DDC2015 has attracted about 290 participants from 25 countries.
          We hope that you will enjoy the DDC2015 and that your interactions with colleagues from different countries will stimulate a creative exchange of ideas and collaborative research projects in the future. We also hope that you will find time to explore and discover the very beautiful and exciting city of Riga.

On behalf of the InnovaBalt project

Coordinator, Prof. Ivars Kalviņš

On behalf of the Organizing Committee

Conference Chair Maija Dambrova

On behalf of the Latvian Institute of Organic Synthesis

Director Osvalds Pugovičs

GENERAL INFORMATION

Dates

August 27-29, 2015.

Conference venue
Radisson Blu Hotel Latvija,
Elizabetes 55, LV-1010, Riga
2nd floor Conference Halls Omega 1 and Omega 2

Registration desk
Conference Hall Foyer, 2nd floor, August 27, 9.00-18.00

Upon registration you will receive:

  • Name Badge (you are kindly requested to wear your badge during all conference sessions and events),
  • Programme/Abstract book,
  • Certificate of Attendance.


Coffee and lunch breaks
Will be served in the designed areas as per schedule.

Poster session
Posters (at a max height 250cm x 100cm base) will be displaced in the Foyer area, 2nd floor, from Thursday, August 27 morning until the end of the conference.

Presenting authors are required to be available for discussion at their poster to answer questions during the specified time indicated below.
August 28: Odd numbered poster presenters 12:00-13:00
August 29: Even numbered poster presenters 12:00-13:00

 



Conference PROGRAMME

Thursday, August 27

Latvian Institute of Organic Synthesis, Aizkraukles Str 21

Opening of the commemorative plaque in tribute to prof. Solomon Hiller

9:30

Departure from The Radisson Blu Hotel Latvia to Latvian Institute of Organic Synthesis

10:00

Opening of the commemorative plaque in tribute to prof. Solomon Hiller

Prof. Jānis Stradiņš, Prof. Ivars Kalvins

10:30

Departure to The Radisson Blu Hotel Latvia

Hall Omega 1

Morning session: “50 years of CHC”

Prof. Ivars Kalvins

Hall Omega 2

O2k Workshop

Prof. Erich Gnaiger

11:00-11:10

 

Welcome: Editor-in-chief, prof. Ivars Kalvins

 

11:00-14:00

High-resolution respirometry  and O2k-Fluorometry

Applications in mitochondrial physiology and drug discovery. 

Lecturer: Prof. Erich Gnaiger

11:10-11:30

CHC-50 years of history

 

11:30-12.15

 

PL7.Plenary lecture: Prof. Vladimir Gevorgyan, University of Illinois at Chicago, Chicago, USA : Novel transition metal-catalyzed approaches toward heterocycles

 

12.25-12.40

Coffee break

12:40-13:10

 

OP1. Prof. Leonid G. Voskressensky, Peoples’ Friendship University of Russia, Russian Federation: Alkynes in domino approaches towards N-heterocycles. Recent advances

 

13:15-13:45

 

OP2. Prof. Yuriy G. Shermolovich,  Institute of Organic Chemistry, Ukraine: Sulfur-containing reagents for fluorinated heterocycles synthesis

 

14:00-15:00

Lunch

 

Hall Omega 1

InnovaBalt Steering Committee meeting/Stake holder session:

Industry and academia collaboration

Dr. Osvalds Pugovics, Dr. Andis Slaitas, Dr. Maija Dambrova

14:30-15:30

Prof. Dr. Paul Finn, InhibOx, UK

Prof. Dr. Tangui Maurice, CNRS, France

Prof. Dr. Erich Gnaiger, Medizinische Universitat Innsbruck, OROBOROS     Instruments, Austria

Dr. Ilmārs Stonāns, JSC "Grindeks", Latvia

Dr. Andis Slaitas, InGre Solutions, Latvia

Dr. Vilnis Liepiņš, JSC "Olainfarm", Latvia

15:35-16:00

Coffee break


 

SCIENTIFIC SESSIONS I

16:00-18:00

Hall Omega 1

Session-Chemistry:

Silicon in medicinal chemistry

Drs. V. Ryabova/L. Ignatovich

Hall Omega 2

Session-Chemistry & Biology:

Methylation and acetylation marks in epigenetics

Dr. P. Trapencieris

 

OP3. Prof. Dr. Reinhold Tacke, Institut für Anorganische Chemie, Germany: The carbon/silicon switch strategy as a tool for drug design

OP8. Prof. Frank Dekker,  Groningen University, Netherlands: Aqueous oxidative Heck reaction as a novel protein labeling strategy

 

OP4. Dr. Florine Cavelier,

Institut des Biomolecules Max  Mousseron, France: Synthesis of silylated amino acids and application in peptide-based drug design

OP9. Prof. Lucia Altucci, Univ. Degli Studi di Napoli, Italy: HDAC inhibitors in the treatment of leukemia: understanding mechanism(s) of responsiveness or resistance

 

OP5. Prof. Troels Skrydstrup, Aarhus University, Denmark: New applications of organosilicon compounds in drug discovery

OP10. Prof. Brian Lohse, University Copenhagen, Denmark: Discovery of small molecules and peptides, as epigenetic chemical compound tools, using DNA encoded libraries for HDM and HMT

 

 

OP6. Jana Spura, Latvian Institute of Organic Synthesis, Latvia: Hetarylsilanes (germanes), synthesis, structure and biological activity

 

 

OP7. Prof. Vladimir Gevorgyan, University of Illinois at Chicago, USA: Silicon tether motif in C-H activation reactions

 

Hall Omega 1

Opening

Conference Chair:  Dr. Maija Dambrova, InnovaBalt Coordinator Prof. Ivars Kalviņš

18:30-20:00

PL1. Plenary lecture: Prof. Helgi Schiöth, Uppsala University, Sweden

Human drug targets: Major shifts in molecular class and indications

 

PL2. Plenary lecture: Prof. Jānis Stradiņš, LAS, Latvian Institute of Organic Synthesis, Latvia

S. Hiller and Latvian Institute of Organic Synthesis

 

Welcome addresses, awards

20.00-22:00

Hotel  restaurant 1st floor

Welcome

 


 

Friday, August 28

9:00-9:45

Hall Omega 1

PL3. Plenary lecture: Claudiu T.Supuran, University of Florence, Italy:

Carbonic anhydrase IX: a membrane protein drug target for anticancer and antimetastatic agents

9:45-10:00

Coffee break

SCIENTIFIC SESSIONS II

10:00-12:00

Hall Omega 1

Session-Chemistry

Carbonic anhydrases in drug discovery

Dr. R. Žalubovskis

Hall Omega 2

Session-Pharmacology

Novel targets for the pharma-cology of heart and vessels

Prof. M. Dambrova, Dr. Edg. Liepins

 

OP11. Jean-Yves Winum, Institut des Biomolécules Max Mousseron Montpellier,  France: What’s New in the Design of Carbonic Anhydrase Inhibitors?

OP14. Prof. Stefan Chlopicki, JCET, Poland: Towards experimental pharmacology of endothelium; focus on prostacylin (PGI2) and nitric oxide (NO)

 

OP12. Giuseppina de Simone, University of Naples, Italy: Carbonic anhydrase IX as a target for the development of new antitumor drugs

OP15. Dr. Hector Alejandro Cabrera-Fuentes, Justus-Liebig-Universität, Germany: The damaging nature of extracellular RNA in cardiac ischemia/reperfusion injury: prevention of cardiomyocyte death and heart failure by RNase1

 

OP13. Raivis Žalubovskis,  Latvian Institute of Organic Synthesis, Latvia: Inhibitors of carbonic anhydrases – chalanges of design and synthesis

OP16. Dr. Edgars Liepins, Latvian Institute of Organic Synthesis, Latvia: Long chain acylcarnitines: new target for treatment of cardiovascular diseases and type 2 diabetes

 

 

OP17. Dr. Reinis Vilskersts,  Latvian Institute of Organic Synthesis, Latvia: Attenuation of atherosclerosis development by targeting acylcarnitine pools

12:00-13:00

Lunch/Poster session I (Odd poster numbers 1, 3, 5...)

13:00-14:00

Hall Omega 1

PL4. Plenary lecture:   Prof. Edwin Vedejs, Latvian Institute of Organic Synthesis, Latvia:

Sixty years after discovery of the mitomycins: selected highlights regarding chemistry and biology of aziridinomitosenes


 

SCIENTIFIC SESSIONS III

14:00-16:00

Hall Omega 1

Session-Chemistry

Natural compounds in drug discovery

Prof. E. Suna

Hall Omega 2

Session-Pharmacology

Targeting mitochondria: bioenergetics and therapeutics, Dr. J. Kuka/Prof. D. Hausenloy

 

OP18. Prof. Ari Koskinen, University of Helsinki, Finland: Efficient stereochemical protection in the synthesis of pharmacologically active alkaloids

OP22. Prof. Derek John Hausenloy, UCL, Hatter Cardiovascular Institute, UK: Mitochondria therapeutic targets for cardioprotection

 

OP19. Prof. Jean François Poisson,  Université Joseph Fourier, France: Total synthesis of lycorine alkaloids

OP23. Prof. Erich Gnaiger, Medizinische Universitat Innsbruck, Austria: A lifestyle drug for mitochondrial fitness – from respiratory mitochondrial diagnosis to therapy

 

OP20. Prof. Jarl Wikberg, Uppsala University, Sweden: Libiguins - new promising remedies for treatment of erectile dysfunction

OP24. Prof. Srecko Gajovic, University of Zagreb, Croatia: In vivo imaging modalities to visualize mouse brain molecular response after stroke using Glowbrain platform

 

OP21. Prof. Petri Pihko, University of Jyvaskyla, Finland: Noncovalent interactions in organocatalysis

OP25. Prof. Mathias Ziegler, Bergen, Norway: The NAD metabolome - bioenergetics, signaling and emerging therapeutic applications

OP26. Marina Makrecka-Kuka, Latvian Institute of Organic Synthesis, Latvia: Acylcarnitines in mitochondrial bioenergetics

16:00-16:30

Coffee break

SCIENTIFIC SESSIONS IV

16:30-18:30

Hall Omega 1

Session-Chemistry

Regenerative medicine: Stem cells, pluripotent cells, differentiation, dedifferentiation, Gene and drug delivery 

Dr. D. Schade/Prof. G. Duburs

Hall Omega 2

Session-Pharmacology

Protein x-ray crystallography in drug discovery

Prof. K.Tars

 

OP27. Dr. Dennis Schade, TU Dortmund University, Germany: Medicinal chemistry for stem cells and heart regeneration

OP32. Prof. Michael McDonough, University of Oxford, UK: Structural investigations on the inhibition of metallo-beta-lactamases

 

OP28. Prof. Lidija Milkovic, Neven Žarkovič, Rudjer Boškovič Institute, Croatia: 4-Hydroxynonenal: Friend or foe of growth regulation

OP33. Prof. Kaspars Tars, Latvian Centre of Biomedical research and studies, Latvia: Crystallographic studies of yeast produced human carbonic anhydrase IX catalytic domain

 

OP29. Prof. Una Riekstina, University of Latvia, Latvia: Skin-derived mesenchimal stem cell neurodifferentiation as in vitro model for drug testing.

OP34. Dr. Janis Kuka, Latvian Institute of Organic Synthesis, Latvia: The comparative anti-infarction activity of selective L-carnitine transport and biosynthesis inhibitors 

 

OP30. Dr. Eriks Jakobsons, Pauls Stradins Clinical University Hospital, Latvia: Practical aspects of bone marrow mononuclear cell extraction

OP35. Gints Kalnins, Latvian Centre of Biomedical Research and Studies, Latvia: Structure and function of bacterial trimethylamine producing enzymes

 

OP31. Prof. Marjo Yliperttula, University of Helsinki, Finland: Confirmed structure-based dynamics of PLL- and PEI-DNA nanoparticles

Why PEI works, but PLL does not in DNA nanoparticle delivery?

 

20:00-21:00

Riga Latvian Society House, Merkela street 13, Riga

Social event, Mixed choir “Sōla” concert, http://www.sola.lv/en

 

Saturday, August 29

9:00-9:45

Hall Omega 1

PL5. Plenary lecture: Eric Bacqué, TSU Infectious Diseases, Sanofi, France

The medicinal chemistry challenges of the discovery of new Anti-Gram(-)

9:45-10:00

Coffee break

SCIENTIFIC SESSIONS V

10:00-12:00

Hall Omega 1

Session-Chemistry

Antiinfectives - novel targets and magic bullets

Prof. A. Jirgensons

Hall Omega 2

Session-Pharmacology

Sigma receptor as a new drug target

Dr. L. Zvejniece

 

OP36. Michael Blackman, NIMR, UK: Dissecting the regulation and dynamics of malaria parasite egress

OP40. Dr. Tangui Maurice, CNRS, France: Development of sigma-1 receptor agonists as neuroprotectants in Alzheimer's disease and related dementia

 

OP37. Kristaps Jaudzems, Latvian Institute of Organic Synthesis, Latvia: Fragment based discovery of 2-aminoquinazolin-4-ones as novel anti-malarial agents targeting plasmepsins

OP41. Prof. M.V. Voronin, Prof. Sergei B Seredenin,  State Foundation Institute of Pharmacology, Russia: Pharmacological effects of sigma-1 receptor ligand activation

 

OP38. Gabriele Costantino, University of Parma, Italy: Targeting the sulphur assimilation pathway in search for new antibacterials

OP42. Dr. Liga Zvejniece, Latvian Institute of Organic Synthesis, Latvia: Stereoselective pharmacological activity of 4.5-disubstituted piracetam derivatives, positive allosteric modulators of Sigma-1 receptor

 

OP39. Frederik Deroose, Asclepia MedChem Solutions, Belgium: Collaboration and funding to clinical trials for European anti-infective Gram negative programmes

OP43. Edijs Vavers, Latvian Institute of Organic Synthesis, Latvia: Ligands of sigma-1 receptor: agonists, antagonists, allosteric modulators

 

 

OP44. Prof. S.A. Kryzhanovsky, Russia: Sigma receptors as novel biological target for cardiotropic drugs

12:00-13:00

Lunch/Poster session II (Even poster numbers 2, 4, 6...)

13:00-14:00

Hall Omega 1

PL6. Plenary lecture: Prof. Ad IJzerman, Leiden University, Leiden, Netherlands: Kinetics in drug discovery. A case for G protein-coupled receptors

SCIENTIFIC SESSIONS VI

14:00-16:00

Hall Omega 1

Session-Chemistry

G protein – coupled receptors: ligands for medicinal chemistry,

Prof. G. Duburs

Hall Omega 2

Session-Pharmacology

Structure​ pharmacophores for novel psychotropic drug design, Prof. B. Jansone, Prof. V. Klusa

 

OP45. Dr. Maris Vilums, Syncom BV, The Netherlands: Small Changes for long term impact – optimization of structure kinetic properties: a case of CCR2 antagonists

OP49. Prof. Vija Kluša, Prof. Ruta Muceniece, Dr. Zane Dzirkale, University of Latvia, Latvia: Lunasin molecule: a source for the design of novel antipsychotics

 

OP46. Dr. Dāvids Fridmanis, Dr. Jānis Kloviņš, Latvian Centre of Biomedical Research and Studies, Latvia: Identification of regions responsible for intracellular retention and ligand recognition specificity of ACTH receptor (MC2R)

OP50. Prof. Baiba Jansone et al., University of Latvia, Latvia: Novel dihydropyridine derivative with memory-improving activity in vivo

 

OP47. Prof. Ago Rinken, Tartu University, Estonia: Fluorescence probes for characterization GPCR co mplexes

 

 

OP51. Dr. Ulrika Beitnere et al., University of Latvia, Latvia: Mildronate and dihydropyridine derivative AV-6-93 in neurodegeneration and stress: focus on brain synaptic plasticity protein expression

OP52. Vladimirs Pilipenko et al., University of Latvia, Latvia: Muscimol effectively reverses impaired spatial memory in Alzheimer's disease-type streptozocin icv rat model

 

OP48. Dr. Einars Loza, Olga Bobiļeva, Latvian Institute of Organic Synthesis, Riga, Latvia :
(E)-2-(acrylamide)cyclohex-1-enecarboxylic acid derivatives-Novel group of hydroxylcarboxylic acid receptor ligands

OP53. Raimonds Skumbiņš et al., University of Latvia, Latvia: Polyprenols and their influence on muscle strength and CNS functions

16:00-16:30

Coffee break


SCIENTIFIC SESSIONS VII

16:30-18:30

Hall Omega 1

Session-Chemistry

Anticancer and antimutagenic agents

 Prof. G. Duburs

Hall Omega 2

Session-Chemistry

Epigenetics and histone deacylases

Dr. P. Trapencieris

 

OP54. Prof. Koen Augustyns, University of Antwerp, Belgium: Activity-based probes to image proteolytic activity in oncology

OP59. Prof. Philippe Bertrand, University of Poitiers, Poitiers, France: Histone deacetylase inhibitors-polymer conjugates for the epigenetic treatment of cancers

 

OP55. J.Molnar, University of Szeged, Szeged, Hungary: Chemotherapy of cancer cells by reversal of multidrug resistance

OP60. Dr. Einars Loza, Latvian Institute of Organic Synthesis, Latvia: Histone deacetylase inhibitors. Discovery of Belinostat

 

OP56. Elina Sokolova, Ilona Domracheva, Dr. Irina Shestakova, Latvian Institute of Organic Synthesis, Latvia: Novel class of multitarget modulators of ABC-transportes: Thieno[2,3-b]pyridines

 

OP61. Prof. Ganesan, University of East Anglia, UK: LSD1: A decade long trip from discovery to clinical trials

 

OP57. Kristine Osina, Evita Rostoka, University of Latvia, Latvia: In vivo experiments aimed on search for molecules with both antioxidant and DNA repair enhancing activities

OP62. Dr. Peteris Trapencieris,  Latvian Institute of Organic Synthesis, Latvia: Search for new epigenetic enzyme inhibitors

 

OP58. Elina Leonova, Latvian Institute of Organic Synthesis, Latvia: Affinity to DNA and other activities of a series of 1,4-dihydropyridines

 

Gallery - Photo from the Drug Discovery Conference and from the opening of the commemorative plaque in tribute to Professor Solomon Hiller, founder of Latvian Institute of Organic Synthesis

 

P. Walden Symposium

May 21-22, 2015 Paul Walden Symposium will take place in in Latvian Institute of Organic Synthesis, http://www.walden.lv/

G.Vanags conference

May 16-17, 2016 International conference on organic and medicinal chemistry dedicated to Professor Gustavs VANAGS’ 125 years anniversary will take place in Riga. Venue: Albert Hotel, 33 Dzirnavu Street.

Agenda

Registration

BOS-2016 pre-conference

June 30 - July 1, 2016 pre-BOS (Balticum Organicum Syntheticum) meeting will take place in Riga, Latvian Institute of Organic Synthesis, Aizkraukles str.21.

Agenda of meeting

BOS-2016 conference

More information: www.boschem.eu

Participation of LIOS researchers in capacity building events

International conferences:
1. 2nd Satellite Meeting on Carbonic Anhydrases, Naples, Italy, 23.-25.10.2013.
2. 12th Annual Meeting of the Society for Heart and Vascular Metabolism - Strategies for recovering metabolic homeostasis and ventricular function in the diseased heart, Tromsø, Norway, 24.-28.06.2014.
3. 8th Biennial International Conference on Organic Synthesis, Balticum Organicum Syntheticum (BOS- 2014), Vilnius, Lithuania, 05.-09.07.2014.
4. 17th International Symposium on Silicon Chemistry, jointly with the 7th European Silicon Days, Berlin, Germany, 02.-09.08.2014.
5. 6th EuCheMS Organic Division Young Investigator Workshop (YIW), Larnaca, Cyprus, 27.-31.08.2014. After this conference article – P.Arsenyan, A.Petrenko, S.Belyakov Improved conditions for the synthesis and transformations of aminomethyl selenophenothiophenes. Tetrahedron, 2015, 71(15), 2226-2233 (doi:10.1016/j.tet.2015.02.078) was published by acknowledgement to REGPOT-CT-2013-316149-InnovaBalt project for dissemination of preliminary results.
6. XXIII International Symposium on Medicinal Chemistry (EFMC-ISMC 2014), Lisbon, Portugal, 07-11.09. 2014
7. 30th International Symposium on Chromatography (ISC 2014), Salzburg, Austria, 14-18.09. 2014. (PDF)
8. Fragment-based Lead Discovery Conference 2014  (FBLD 2014), Basel, Switzerland, 21-24.09. 2014.
9. 50 Years of Histone Acetylation. (BCEC 2014) Barcelona Conference on Epigenetics and Cancer. Barcelona, Spain, 01.-02.10.2014.
10. 9th International Conference of Anticancer Research, Sithonia, Greece, 06.-10.10.2014.
11. 17th International Neuroscience Winter Conference, Sölden, Austria, 7-11.04. 2015.
12. 10th International Carbonic Anhydrase Conference, Maastricht, Netherlands, 20-22.04.2015.
13. EU FP7 Project GlowBrain Final Conference "Stem cell and biomaterial applications for brain repair", Zagreb, Croatia, May 27-30, 2015.
14. XVI International Conference on Heterocycles in Bioorganic Chemistry (Bioheterocycles 2015), Metz, France, June 8-11, 2015.
15. Tetrahedron Symposium 2015 - Challenges in Bioorganic & Organic Chemistry,  Berlin, Germany, June 16-19, 2015.
16. 2nd International Conference on Nanomaterials & Applications (NANOAPP 2015), Maribor, Slovenia, June 23-26, 2015.
17. 18th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 18), Sitges, Barcelona, Spain, June 28 – July 2, 2015.
18. 7th EuCheMS Organic Division Young Investigator Workshop (YIW), Aveiro, Portugal, July 9-11, 2015.
19. Spanish-Italian Medicinal Chemistry Congress (SIMCC 2015), Barcelona, Spain, July 12-15, 2015.
20. 19th European Symposium of Organic Chemistry (ESOC-2015), Lisbon, Portugal, July 12-16, 2015.
21. 29th Conference of the European colloid and interface society (ECIS-2015),  Bordeaux, France, September 6-11, 2015.
22. Barcelona BioMed Conference, Barcelona, Spain, November 2-4, 2015.
23. 6th EFMC (European Federation for Medicinal Chemistry) International Symposium on Advances in Synthetic and Medicinal Chemistry, Rehovot, Israel, November 15-18, 2015.
24. European Nanomedicine Meeting - ENM 2015, Grenoble, France, December 7-9, 2015.
25.
 
Second Anatolian Conference on Synthetic Organic Chemistry (ACSOC-II). Kusadasi, Aydın, Turkey, March 21-24, 2016.
26. 9th International Symposium on Neuroprotection and Neurorepair, Leipzig, Germany, April 19-22, 2016.
27. Mitochondrial Medicine: Developing New Treatments for Mitochondrial Disease, Cambridge, UK, May 4-6, 2016.
28. Chianti Workshop: Magnetic Resonance for Cellular Structural Biology, Grosseto, Italy, June 5-10, 2016.
29. IARC (International  Agency for Cancer Research) conference " Global Cancer: Occurrence, Causes, and Avenues to Prevention".  Lyon, France, June 7-10, 2016.
30. 10th PAMIR International Conference Fundamental and Applied MHD, Cagliari – Sardinia, Italy, June 20-24, 2016.
31. 7th European Congress of Pharmacology (EPHAR 2016), Istanbul, Turkey,  June 26-30, 2016.
32. 2nd International Conference “Current Trends of Cancer Theranostics” (CTCT-2016), Druskininkai, Lithuania, June 19-23, 2016.
33. 17th Tetrahedron Symposium, Sitges (near Barcelona), Spain June 28-July 1, 2016.
34. ECHC 2016, XXVII European Colloquium on Heterocyclic Chemistry, Amsterdam, The Netherlands - July 3-6, 2016.
35. EUROMAR 2016, Aarhus, Denmark, July 3-7, 2016.
36. 13th International Conference on Nanosciences and Nanotechnologies (NN16), Thessaloniki, Greece, July 5-8, 2016.
37. 15th Belgian Organic Synthesis Symposium (BOSS XV), Antwerp, Belgium, July 10-15, 2016.
38. 27th International Symposium on Organic Chemistry of Sulfur „From fundamental research to application“, Friedrich-Schiller-University Jena, Germany, July 24-29, 2016.
39. XXIV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2016), Manchester, UK, August 28 – September 1, 2016.
Seminars and info day events:
1. Open Info Day Horizon 2020 „Health, demographic change and well being”, Brussels, Belgium, 21.-22.11.2013.
2. 3rd EUOPENSCREEN stakeholder meeting Open Science Day, Oslo. Norway, 19.-21.11.2013.
3. Vilnius Innovation Forum 2013 „Innovation Drift”, Vilnius, Lithuania, 03.-06.12.2013.
4. European Academy organized interactive seminar "Financial Accounting and Audit in European Research and Development", Berlin, Germany, 20.-21.02.2014.
5. EC organized information day „Spreading excellence and Widening participation in Horizon2010”, Brussels, Belgium, 3.07. 2014.
6. “Brokerage Event for Nanotechnologies, Advanced Materials, Biotechnology and Advanced Manufacturing and Processing” Brussels, Belgium, 13.11.2014.
7. 7th EuroNanoForum 2015, Riga, Latvia, June 10-12, 2015.
8. Information Day – Biobased Industry, Brussels, Belgium, June 26, 2015.
9. Visit to the Pfizer Process Development Centre, Loughbeg, Co. Cork, Ireland, July 30 – August 01, 2015.
10. EC organized Infoweek on Horizon2020 Societal Challenge 2 work programme 2016-2017, Brussels, Belgium, November 24-26, 2015.
11. The workshop „Contribution of "Research Potential" (REGPOT) and "Regions of Knowledge" (ROK), the way forward thanks to synergies between EU policies/funds”, Brussels, Belgium, December 7, 2015.
12. Info Day on “Spreading Excellence and Widening Participation" Calls 2016, Brussels, Belgium, February 2, 2016.
13. Week of Innovative Regions in Europe 2016 (WIRE 2016), Eindhoven, The Netherlands, June, 8-10, 2016.
14. ECHC 2016, XXVII European Colloquium on Heterocyclic Chemistry Amsterdam, The Netherlands, July 3-6, 2016.

Consortium meeting for proposal preparation
1. Consortium meetings for the preparation of proposal for Horizon2020 Call H2020-MSCA-ITN-2014 (Innovative Training Networks), Brussels, Belgium, 7.02.2014. and
18.-20.03.2014. The proposal INTEGRATE (Interdisciplinary Training Network for Validation of Gram-Negative Antibacterial Targets) was submitted on 09/04/2014 and, after evaluation, was invited to project grant agreement (No 642620) preparation.
Implementation of project has started from 01.01.2015.
2. Consortium meetings for the preparation of proposal for Horizon2020 Call H2020-PHC-2015 “New therapies for Rare Diseases”, London, United Kingdom, September 4-5, 2014 and January 14-16, 2015. The proposal was submitted in the 1st stage of call. After the evaluation consortium was invited to prepare proposal for the 2nd stage of call. Full proposal was prepared and submitted on 21.04.2015.  As a result, the proposal was highly scored: total score was 14.50 (Threshold: 12) and it was suggested for financing. The funding for the researchers in the Latvian Institute of Organic Synthesis: EUR 399 625. The evaluators concluded that the proposal has excellent innovation potential because the project will not only benefit Batten disease patients but also other patients and future research of other rare diseases related to lysosomal pathologies.
 
3. Consortium kick-off meeting for the ERA-NET NEURON project CnsAflame „Neuroinflammatory mechanisms of chronic neurodegeneration and cognitive decline following traumatic brain injury”, Munich, Germany, July 30-31, 2015. The meeting was organized by the Project Coordinator Dr. Nikolaus Plesnila (University of Munich Medical Center Institute for Stroke and Dementia Research). Researchers from 5 countries (Germany, France, Sweden, Israel and Latvia) were present to discuss collaboration, deliverables, and milestones and to draft a Consortium Agreement.
 
4. The EU H2020-PHC-2015-two-stage project Nr.666918-2 „Developing new therapies for Batten disease” BATCure kick-off meeting University College of London, UK, January 27-29, 2016. BATCure Research Consortium headed up by Dr Sara Mole at University College London has been awarded an EU Horizon2020 Innovation Grant of 6 million EUR to investigate potential therapies for Batten’s disease and related lysosomal diseases. BATCure represent a widespread European consortium with 14 partners/participants from 7 different countries from the north, south, west and east of Europe. 10 of the partners are academic, including 1 who works daily in a clinical environment, 3 are SMEs and 1 is a patient organisation. During the kick-off meeting representatives from partnering organizations discussed work-flow, schedule for deliverables and milestones. IOS researchers will participate in WP5 (low-molecular weight molecules for therapy) and WP7 (In vivo pharmacology and toxicology). M. Dambrova presented Communication Lead activities.
 
5. Visit  to Karolinska Institutet and discussion for the preparation of joint proposal for Horizon2020 call "WIDESPREAD-04-2017 - Teaming Phase 1"