Footnotes Electronic supplementary material The online version of this article doi: The advent of next-generation sequencing NGS has allowed for the efficient, cost-effective analysis of many genes simultaneously. Breast Cancer Res Treat. Positive results do not imply that there are no other contributions, genetic or otherwise, to the patient's phenotype, and negative results do not braca panel breast cancer out a genetic cause for the indication for testing.

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Gene panel testing for inherited cancer risk. Overview of genes included in Breast ovarian cancer panel.

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Individuals with heterozygous variants in tumor suppressor genes have an increased breast cancer risk of between 1. We hypothesized that using broader gene panels increases the identification of clinically significant findings, some relevant and others incidental to the testing indication. The results showed a pathogenic variant in CHEK2.

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Red flags for hereditary breast cancer could include onset of cancer prior to the age of 50 years, more than one primary cancer in a single person, and multiple affected people within a family. CHEK2 is a multiorgan cancer susceptibility gene.